Foreword by George F. Koob -- Section I. Neurobiology of Stress and Addiction. -- Biological Bases of the Stress Response. -- The Hypothalamic-Pituitary-Adrenal Axis and Addiction. -- Dopaminergic Reward Pathways and Effects of Stress. -- Endogenous Opiates, Addiction, and the Stress Response. -- Early Life Stress and Vulnerability to Addiction. -- Genetics, Stress and the Risk for Addiction . -- Neurobiology of Stress and Risk for Relapse. -- Section II. Psychosocial Processes Related to Stress and Addiction. -- Negative Affect and Addiction. -- Stress and Impulsive Behaviors. -- Psychosocial Determinants of the Stress Response. -- Individual Differences in Response to Stress and Risk for Addiction. -- Addiction and Stress in Adolescents. -- -- Section III. Clinical Implications: Assessment and Intervention. -- The Assessment of Stress in Research and Clinical Settings. -- Assessment of Addictions in Clinical and Research Settings. -- Stress, Anxiety and Addiction: Intervention Strategies. -- Posttraumatic Stress Disorder and Substance Use Disorders. -- Novel Pharmacologic treatment of Stress and Addiction: The Role of CRF and Glucocorticoid Antagonists. -- Future directions of research on stress and addictive behaviors.